The activities in the computing infrastructures domain encompass the support to scientific research, the participation in R&D projects aimed at keeping LIP in the forefront of IT technologies, and the participation in digital infrastructure initiatives. These activities are mainly focused on distributed computing, cloud computing, High Performance Computing, High Throughput Computing, grid computing and on the challenges of big data in research.

LIP is member of the Portuguese National Advanced Computing Center (CNCA) formerly known as INCD. CNCA is a digital infrastructure in the context of the Portuguese Roadmap of Research Infrastructures of Strategic Interest of FCT the Portuguese national funding agency for science, research and technology. CNCA provides computing and data services to the national scientific and academic community in all domains. It supports researchers and their participation in national and international research projects.

LIP participates actively in several international computing infrastructures acting as national contact point, namely: Worldwide LHC Computing Grid (WLCG), European Grid Infrastructure (EGI), Iberian Grid Infrastructure (IBERGRID). LIP participates in several projects in the framework of the European Open Science Cloud (EOSC). LIP also participates in the national competence center (NCC) in the context of EuroCC and EuroHPC.

LIP has been participating in many R&D projects in the context of the European framework programmes, among them: EGI–ENGAGE (H2020), INDIGO-DATACLOUD (H2020), EOSC-hub (H2020), DEEP-Hybrid-DataCloud (H2020), EOSC-synergy (H2020), EuroCC (H2020), EOSC-Future (H2020), EGI-ACE (H2020), DT-GEO (H.Europe), interTwin (H.Europe), iMagine (H.Europe), AI4EOSC (H.Europe), EOSC-Beyond and ENVRI-Hub-NEXT.